Merkel Cell Polyomavirus Strains in Patients with Merkel Cell Carcinoma

نویسندگان

  • Antoine Touzé
  • Julien Gaitan
  • Annabel Maruani
  • Emmanuelle Le Bidre
  • Angélique Doussinaud
  • Christine Clavel
  • Anne Durlach
  • François Aubin
  • Serge Guyétant
  • Gérard Lorette
  • Pierre Coursaget
چکیده

We investigated whether Merkel cell carcinoma (MCC) patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens and 45% of formalin-fixed and paraffin-embedded specimens, but none of the non-MCC neuroendocrine carcinomas specimens, had MCPyV. Strains from France and the United States were similar.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Merkel cell carcinoma in an immunosuppressed patient*

Merkel cell carcinoma is an uncommon neuroendocrine carcinoma with a rising incidence and an aggressive behavior. It predominantly occurs in older patients, with onset occurring at a mean age of 75-80 years. Recognized risk factors are ultraviolet sunlight exposure, immunosuppression, and, more recently, Merkel cell polyomavirus. We report a case of Merkel cell carcinoma in a young HIV positive...

متن کامل

Merkel Cell Polyomavirus in Cutaneous Swabs

To assess the usefulness of using cutaneous swabs to detect Merkel cell polyomavirus (MCPyV) DNA, we analyzed swabs from persons with Merkel cell carcinoma (MCC), others with skin diseases, and healthy volunteers. MCPyV was detected in at least 1 sample from virtually all participants. Viral loads were higher in samples from patients with MCC.

متن کامل

Complete Spontaneous Regression of Merkel Cell Carcinoma

I read the article "Complete spontaneous regression of Merkel cell carcinoma metastatic to the liver: Did lifestyle modifications and dietary supplements play a role?"(1) with great interest. Merkel cell carcinoma carries a significant rate of recurrence and mortality.(2) Though spontaneous regression of Merkel cell carcinoma has been well documented in the literature,(3) the potential that the...

متن کامل

Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma.

BACKGROUND Merkel cell carcinoma is a rare malignancy of the skin. Integration of Merkel cell polyomavirus (MCPyV) DNA to the tumor genome is frequent in these cancers. The clinical consequences of MCPyV infection are unknown. METHODS We analyzed formalin-fixed paraffin-embedded Merkel cell carcinoma tissue samples from 114 of 207 patients diagnosed with Merkel cell carcinoma in Finland from ...

متن کامل

Merkel Cell Polyomavirus Infection in a Patient With Merkel Cell Carcinoma: A Case Report

INTRODUCTION Merkel cell carcinoma (MCC) is a rare and highly aggressive malignancy of the skin which occurs mainly in old people and is very uncommon in young individuals. A new tumor virus belonging to the Polyomaviridae family; Merkel Cell Polyomavirus (MCPyV) has recently been identified in more than 80% of MCCs. CASE PRESENTATION We conducted a retrospective review on the archives of the...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2009